Study reported here used information from existing rs 3 gold data sources to build a statistical model to predict association between RBC folate concentration at time of neural tube closure (embryologic day 28) and risk of neural tube defectsOpen in new tabTo investigate this question, we used existing data sources to assess the potential association between red blood cell folate concentrations at the time of neural tube closure (embryologic day 28) and risk of neural tube defects among participants in the Community Intervention Project (China 1993 95; n=247831).1 15 24 29 30 31 We then compared the estimated association developed in this analysis with that observed in the Irish population reported by Daly and colleagues.28 We also used the modeled association to predict risk of neural tube defects in the US population before and after fortification from published population based distributions of red blood cell folate concentrations.
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